解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The eyes and pineal glands from 10 monkeys immunized with S-antigen were studied using routine histopathological and immunohistochemical techniques. Seven out of 10 animals developed uveitis between 19 and 33 days after the initial immunization. Histopathology of the eyes harvested 70 days after immunization showed mo...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939209112339
更新日期:1992-01-01 00:00:00
abstract::Experimental autoimmune uveoretinitis (EAU) induced by immunization of albino Lewis rats with a retinal soluble antigen (S-antigen) has been studied extensively by many workers. An intraorchidic injection of S-antigen 4 days prior to immunization of the animal with the antigen emulsified in adjuvant was found to preve...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939209083134
更新日期:1992-01-01 00:00:00
abstract::Eighty-six patients affected by vitiligo were investigated for Gm, and Km polymorphisms, HLA markers and the presence of organ and non organ-specific autoantibodies. Vitiligo patients had an increased frequency of autoantibodies (71%), in particular anti-parietal cells (26.6%), antithyroglobulin (24.4%) and antithyroi...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939209035163
更新日期:1992-01-01 00:00:00
abstract::Thyroid lymphocyte RNA from a Hashimoto patient exhibiting high titre serum IgG autoantibodies against thyroglobulin (Tg) has been used to construct a Fab library in phage lambda. Screening of this library with radioiodinated Tg has permitted the cloning of an anti-Tg antibody (MH52) with an affinity of 4.5 x 10(9) mo...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939209150320
更新日期:1992-01-01 00:00:00
abstract::NZB (H-2d) mice are well known for the production of IgM autoantibodies to ssDNA. However, an F1 cross between NZB and either NZW or SWR mice is required to produce IgG nephritogenic antibodies to dsDNA and glomerulonephritis. The contribution of parental class II loci in the hybrid mice is clearly important to the de...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939108997132
更新日期:1991-01-01 00:00:00
abstract::In the present study, the spontaneous elevation of the transcription of heat shock protein (hsp 70) gene in kidney lymphoid cells of lupus-prone mice (MRL-lpr/lpr) is shown by Northern blot and nuclear run on transcription assay. By quantification analysis of hsp 70 gene transcription, more than ten times of the enhan...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939108997141
更新日期:1991-01-01 00:00:00
abstract::Various amounts of the bacterium, Brucella abortus (BA) were injected intravenously into autoimmune NZB/W F1 mice and non-autoimmune BDF1 mice and then the localization of BA in the thymus was traced using an immunohistochemical method at 30 min and 3 h after injection. The results showed that a greater amount of BA b...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939109004813
更新日期:1991-01-01 00:00:00
abstract::Marked fluctuations in the levels of a common DNA-antibody idiotype, PR4-Id have been found on IgM and IgA antibodies in particular and to a lesser extent on IgG in serial bleeds of 14 lupus patients. Few clear cut examples were found of the PR4-Id levels reflecting disease activity. However, the idiotype expression w...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939108997118
更新日期:1991-01-01 00:00:00
abstract::The class II molecules of the human major histocompatibility complex bind intracellularly processed peptides and present them to T-helper cells. They therefore have a critical role in the initiation of the immune response. A salient feature of the class II molecules is their polymorphism. It has been shown that some a...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.3109/08916939108997111
更新日期:1991-01-01 00:00:00
abstract::Elevated constitutive expression of major histocompatibility (MHC) class II antigens occurs in the enterocytes of patients with IBD. It has been suggested that this aberrant expression of class II molecules may play a role in the pathogenesis of IBD. We examined two possible reasons for such a finding. 1) Heightened s...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939109006750
更新日期:1991-01-01 00:00:00
abstract::This paper describes the idiotypic specificities of eight murine monoclonal antibodies directed to three independent epitopes on retinal S-antigen. The antigenic sites recognised by these monoclonal antibodies have previously been localised to a small region near the C-terminal of bovine S-antigen. Xenogeneic, site-re...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939109006744
更新日期:1991-01-01 00:00:00
abstract::Autoimmune-prone NZB x NZW F1 (B/W F1) mice produce a high titer of anti-DNA antibodies, In vivo and in vitro studies showed that in the early life of these mice, the immunoglobulin isotype of these antibodies almost exclusively belongs to IgM class, however, IgG anti-DNA antibodies begin to develop when the mice are ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939008993383
更新日期:1990-01-01 00:00:00
abstract::The concordance rate of Graves' disease in pairs of identical twins of 30 to 60% points to the influence of environmental factors, and infections have often been incriminated in the pathogenesis. More than 15 years ago we demonstrated an increased frequency of antibodies to Yersinia enterocolitica (Y. ent.) serotype 3...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.3109/08916939009087588
更新日期:1990-01-01 00:00:00
abstract::HLA-DP+ T cells in peripheral blood from 23 patients with systemic lupus erythematosus (SLE) were examined using two-colour flow cytometry analysis. A marked increase of HLA-DP+ T cells was observed in patients with SLE (20.5-98.7%; 59.8 +/- 20.8%) in comparison to normal subjects (1.3-20.6%; 11.1 +/- 7.2%), and the r...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939009002976
更新日期:1990-01-01 00:00:00
abstract::The expression of major histocompatibility complex class II molecules (Ia antigen) has been analyzed by immunoperoxidase staining in thyroids of normal C3H mice, of iodine-deficient mice with a hyperplastic goiter and of mice during goiter involution induced by administration of either a high iodide dose (HID, 10 micr...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939009041050
更新日期:1990-01-01 00:00:00
abstract::Only one out of 57 A-/A- rabbits immunized with rat or guinea-pig myelin developed clinical signs suggestive of EAE. On the contrary, clinical signs of acute or chronic EAE were found in two thirds of the 102 A+/A+ and A+/A- rabbits immunized in the same way. About one third of the diseased animals had reversible acut...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939008993369
更新日期:1990-01-01 00:00:00
abstract::To evaluate changes in TSH receptor antibody after surgery in Graves' disease and its relationship with the degree of lymphocytic infiltration, serial serum levels of TSH receptor antibody were measured before and after the subtotal thyroidectomy in 50 patients with Graves' disease. In 22 (44%) out of 50 patients, thy...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939008995732
更新日期:1990-01-01 00:00:00
abstract::In a previous work we characterized a major epitope of thyroid peroxidase (TPO), which was recognised by 66% of 157 patients with autoimmune thyroid disease (AITD) and 9 out of 50 patients with non-thyroidal autoimmune disease (NTAID) 6 of whom had antibodies to the gastric parietal cell antigen (PCA). In the present ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939008998434
更新日期:1990-01-01 00:00:00
abstract::T lymphocytes present in thyroid infiltrates of 6 patients with Hashimoto's thyroiditis (HT) and of 4 patients with Graves' disease (GD) were analyzed at clonal level and their profiles of mitogen-induced lymphokine secretion were characterized. Production of interleukin-2 (IL-2), interleukin-4 (IL-4), interferon-gamm...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916938909014703
更新日期:1989-01-01 00:00:00
abstract::A patient with chronic ITP relapsed after conventional therapy but following an infusion with low dose anti D (Rho) immunoglobulin, she entered a remission which has now lasted 10 months. This is difficult to explain on the basis of long term macrophage Fc receptor blockade and suggests an alternative mechanism of act...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916938909034366
更新日期:1989-01-01 00:00:00
abstract::Peripheral blood B lymphocytes of multiple sclerosis (MS) patients and control persons were transformed with Epstein-Barr virus. Antibody production of transformed cells against isolated human myelin was investigated by enzyme-linked immunosorbent assay (ELISA). Cells producing reactive antibodies were cloned and prop...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916938909029146
更新日期:1989-01-01 00:00:00
abstract::Adult and one week old marmosets were injected intravenously within a one month period or intraperitoneally within a 6 week period respectively, with monoclonal IgM having an anti-myelin associated glycoprotein antibody activity. No clinical or electrophysiological abnormalities could be detected in experimental anima...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916938909043611
更新日期:1989-01-01 00:00:00
abstract::The HEp2 cell cultures appeared highly sensitive in detecting the antinuclear antibodies (ANAb) in systemic sclerosis, principally anticentromere antibodies of the CREST syndrome. The immunoblotting used with either complex cellular extracts from HeLa and rabbit thymus or purified nuclear components (high mobility gro...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916938909019953
更新日期:1989-01-01 00:00:00
abstract::CNS demyelinating inflammatory disease can be a multifactorial process mediated by cellular and antibody-mediated immune processes. Myelin basic protein (MBP)-specific T cells and pathogenic 8-18C5 antibody, specific for a myelin/oligodendrocyte glycoprotein (MOG), a minor component of CNS white matter, can coexist in...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916938909014690
更新日期:1989-01-01 00:00:00
abstract::We have previously reported that lymphoid cells from systemic lupus erythematosus (SLE) mice with established disease migrate aberrantly. This study evaluates the abnormal lymphocyte migration patterns found in MRL-lpr/lpr (MRL/l) mice in relation to age, disease manifestations and the expression of lymphocyte homing ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916938909043609
更新日期:1989-01-01 00:00:00
abstract::In order to know whether effector cells are capable of recognizing the epidermal targets in pemphigus vulgaris (PV) and bullous pemphigoid (BP), non-adherent cells (NAC) of peripheral blood from 27 primary PV, 19 BP patients and 12 healthy volunteers were used in cytotoxic tests. Autologous, allogenic and murine epide...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916938908997095
更新日期:1989-01-01 00:00:00
abstract::The nature of the immunosuppressive effect of antithyroid drugs has been a subject of controversy. It has been claimed that these agents exert a direct effect on the immune system, although we and others have suggested that the drugs affect the thyroid cells primarily with consequent reduced thyrocyte-immunocyte signa...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916938909019950
更新日期:1989-01-01 00:00:00
abstract::In addition to a lupus-like syndrome and massive T cell proliferation, MRL-lpr/lpr(MRL/l) mice develop an arthritic process very similar serologically and histologically to human rheumatoid arthritis (RA). Recently, we have developed in DBA/1 mice an experimental model of autoimmune arthritis (EAA) which shares clinic...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916938909034357
更新日期:1989-01-01 00:00:00
abstract::Mitochondrial antigens were purified from rat liver and characterized by immunoblotting. Sera from 19 well defined patients with primary biliary cirrhosis (PBC) reacted with two mitochondrial polypeptides of 68 Kd and 45 Kd. Antibodies to these antigens were not detected in any of the sera of patients with cirrhosis o...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916938909014705
更新日期:1989-01-01 00:00:00
abstract::The possible immunosuppressive action of antithyroid drugs in vivo has been assessed using Buffalo (Buf) strain rats with thyroiditis produced by neonatal thymectomy; this model shares many features with spontaneous thyroiditis in man. Both propylthiouracil and methimazole significantly reduced the severity of thyroid...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916938808997176
更新日期:1988-01-01 00:00:00
abstract::Environmental agents have been implicated in the pathogenesis of insulin dependent diabetes (IDD). These studies were designed to learn if dietary protein influences the development of IDD in the BB rat. Specifically, analysis involved the effects of substituting a modified, semi-synthetic diet (AIN-76) containing soy...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916938809019939
更新日期:1988-01-01 00:00:00
abstract::The biological basis for autoimmunity and immunoincompetence in the BB rat has yet to be localized. In spite of normal thymic histology, thymocyte subsets and blastogenesis, thymus gland products (thymosins) have yet to be studied. In the present report, thymus gland function was studied by measuring thymosin alpha 1 ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916938809001924
更新日期:1988-01-01 00:00:00
abstract::Using a novel cytofluorometric method of cellular antigen quantification, we examined peripheral blood mononuclear cells (PBMC) from patients suffering from rheumatoid arthritis (RA) for quantitative modification of class II human leucocyte antigen (HLA) molecules expressed on the surface. Class II HLA molecules were ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916938808997166
更新日期:1988-01-01 00:00:00